In order to contribute to the recovering of organic waste, we collected the crushed kernels of avocado to investigate their combined effects with Pennisetum on different strains of Pleurotus ostreatus. The strains used in this study consist of Pleurotus ostreatus (2125, 969 and 2153). The results of this study showed that Pleurotus ostreatus 2125, 969 and 2153 grown on the substrate consisted of crushed kernels of avocado give a higher yield (yield between 28 and 30%) than that obtained if they were grown on substrate consisted of Pennisetum only (yield between 18 and 20%). The best performance is obtained, however, with Pleurotus ostreatus 2125, 969 and 2153 grown on the substrate consisted of Pennisetum supplemented with crushed kernels of avocado at 30% (yield between 33 and 38%) and 40% (performance ranging between 34 and 36%).