Vaccination strategies to achieve outbreak control for MPXV Clade I with a one-time mass campaign in sub-Saharan Africa: A scenario-based modelling study
| dc.contributor.author | Jin Shihui, | |
| dc.contributor.author | Et al. | |
| dc.date.accessioned | 2025-12-16T17:17:37Z | |
| dc.date.available | 2025-12-16T17:17:37Z | |
| dc.date.issued | 2025-09 | |
| dc.description | Article de recherche | |
| dc.description.abstract | Author summary Why was this study done? • The newly-emergent Clade Ib monkeypox virus (MPXV) can spread more easily between people compared to the previous Clade Ia MPXV, and can be transmitted through both sexual and non-sexual contacts. • Immunity from historical smallpox vaccination, which also offered protection against monkeypox, is waning with the ageing of the vaccinated population, increasing the risk of outbreaks in African countries. • While some countries in Africa began to receive mpox vaccine donations in late 2024, few studies have explored how mpox vaccination could be carried out in Africa, especially for one-time campaigns across sub-Saharan African countries at different time points. What did the researchers do and find? • We provided the first assessment of mpox vaccine demand for one-time mass vaccination across sub-Saharan Africa based on transmissibility projections up to year 2050, adjusted for the diminishing smallpox-immunised population. • The results suggested that as sexual transmission of Clade I MPXV becomes more prevalent, greater vaccination coverage and age-specific targeting would be needed. • We also found that prioritising high-risk age groups, such as children under 5 years and young adults aged 20–29 years, could reduce disease spread more effectively than distributing vaccines evenly across multiple age groups. What do these findings mean? • With increasing Clade I MPXV transmission potential over time and persistent risk of outbreaks, planning one-time mass vaccination campaigns can support effective responses, especially when supplies are limited and multiple countries are affected. • Where increasing sexual transmission is determined, vaccination strategies should adapt by shifting the priority from young children aged under 5 years to adults aged 20–29 years, which would also requires substantially greater minimum vaccination coverage to successfully control outbreaks. • These recommendations were based on information available about how Clade I MPXV was spreading in the Democratic Republic of the Congo up to December 2024. | |
| dc.identifier.citation | Jin S, Asakura TR, Murayama H, Niyukuri D, Saila-Ngita D, Lim JT, et al. (2025) Vaccination strategies to achieve outbreak control for MPXV Clade I with a one-time mass campaign in sub-Saharan Africa: A scenario-based modelling study. PLoS Med 22(9): e1004726. https://doi.org/10.1371/journal.pmed.1004726 | |
| dc.identifier.uri | https://repository.ub.edu.bi/handle/123456789/2158 | |
| dc.language.iso | en | |
| dc.publisher | PLOS Medicine | |
| dc.title | Vaccination strategies to achieve outbreak control for MPXV Clade I with a one-time mass campaign in sub-Saharan Africa: A scenario-based modelling study | |
| dc.type | Article |